Biliary Microbiota in Choledocholithiasis and Correlation With Duodenal Microbiota.

ABSTRACT:

Background

The pathogenesis of choledocholithiasis is closely related to the role of bacteria. However, little is known about the predictive role of bile bacteria in clinical conditions of patients and the compositional and functional characteristics of biliary microbiota in choledocholithiasis.

Methods

To investigate the predictive value of biliary bacteria, clinical data of 488 patients with choledocholithiasis were collected. The predictive value of common bile bacteria to patients' clinical conditions was analyzed by logistic regression. Samples of bile and corresponding duodenal juice from 10 selected patients with choledocholithiasis were obtained, and the composition and function of microbial communities were analyzed based on 16S rRNA sequencing and Tax4Fun.

SUBMITTER: Han J 

PROVIDER: S-EPMC8116743 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature