Anti-inflammatory activity and mechanism of action of ethanolic leaf extract of Morinda lucida Benth.

ABSTRACT:

Background and aim

Most developing countries resort to medicinal plants for treating diseases, but few of these have scientific backing for their use. The aim of the study was to validate traditional use of Morinda lucida leaves in treating inflammation and determine the mechanism of action.

Experimental procedure

Effect of hydroethanolic leaf extract of M. lucida (HEML) on localized inflammation was evaluated using rat paw edema presented by sub-planter injections of λ-carrageenan, histamine or serotonin in separate experiments. Systemic inflammation was evaluated by lipopolysaccharide (LPS)-induced hyperthermia. Antioxidant activity of HEML was also evaluated using the free-radical scavenging assay.

Results and conclusion

No mortalities were rec

SUBMITTER: Ayertey F 

PROVIDER: S-EPMC8116761 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature