Exploring the Link Between Hepatic Perfusion and Endotoxemia in Hemodialysis.

ABSTRACT:

Introduction

The liver receives gut-derived endotoxin via the portal vein, clearing it before it enters systemic circulation. Hemodialysis negatively impacts the perfusion and function of multiple organs systems. Dialysate cooling reduces hemodialysis-induced circulatory stress and protects organs from ischemic injury. This study examined how hemodialysis disrupts liver hemodynamics and function, its effect on endotoxemia, and the potential protective effect of dialysate cooling.

Methods

Fifteen patients were randomized to receive either standard (36.5°C dialysate temperature) or cooled (35.0°C) hemodialysis first in a two-visit crossover trial. We applied computed tomography (CT) liver perfusion imaging to patients before, 3 hours into and after each hemodialysis session. W

SUBMITTER: Marants R 

PROVIDER: S-EPMC8116762 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature