Exploiting Rational Assembly to Map Distinct Roles of Regulatory Cues during Autoimmune Therapy.

ABSTRACT: Autoimmune diseases like multiple sclerosis (MS), type 1 diabetes, and lupus occur when the immune system attacks host tissue. Immunotherapies that promote selective tolerance without suppressing normal immune function are of tremendous interest. Here, nanotechnology was used for rational assembly of peptides and modulatory immune cues into immune complexes. Complexes containing self-peptides and regulatory nucleic acids reverse established paralysis in a preclinical MS model. Importantly, mice responding to immunotherapy maintain healthy, antigen-specific B and T cell responses during a foreign antigen challenge. A therapeutic library isolating specific components reveals that regulatory nucleic acids suppress inflammatory genes in innate immune cells, while disease-matched peptide sequen

SUBMITTER: Oakes RS 

PROVIDER: S-EPMC8116774 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature