Intrathoracic vs Cervical Anastomosis After Totally or Hybrid Minimally Invasive Esophagectomy for Esophageal Cancer: A Randomized Clinical Trial.

ABSTRACT:

Background

Transthoracic minimally invasive esophagectomy (MIE) is increasingly performed as part of curative multimodality treatment. There appears to be no robust evidence on the preferred location of the anastomosis after transthoracic MIE.

Objective

To compare an intrathoracic with a cervical anastomosis in a randomized clinical trial.

Design, setting, and participants

This open, multicenter randomized clinical superiority trial was performed at 9 Dutch high-volume hospitals. Patients with midesophageal to distal esophageal or gastroesophageal junction cancer planned for curative resection were included. Data collection occurred from April 2016 through February 2020.

Intervention

Patients were randomly assigned (1:1) to transthoracic MIE with intrathoracic

SUBMITTER: van Workum F 

PROVIDER: S-EPMC8117060 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature