A Mutational Survey of Acral Nevi.

ABSTRACT:

Importance

Acral skin may develop nevi, but their mutational status and association with acral melanoma is unclear.

Objective

To perform targeted next-generation sequencing on a cohort of acral nevi to determine their mutational spectrum.

Design, setting, and participants

Acral nevi specimens (n = 50) that had been obtained for diagnostic purposes were identified from the pathology archives of a tertiary care academic cancer center and a university dermatology clinic. Next-generation sequencing was performed on DNA extracted from the specimens, and mutations called. A subset of samples was stained immunohistochemically for the BRAF V600E mutation.

Results

A total of 50 nevi from 49 patients (19 males and 30 females; median [range] age, 48 [13-85] years) were ex

SUBMITTER: Smalley KSM 

PROVIDER: S-EPMC8117064 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature