Early Emergence of Adaptive Mechanisms Sustaining Ig Production: Application to Antibody Therapy.

ABSTRACT: Antibody therapy, where artificially-produced immunoglobulins (Ig) are used to treat pathological conditions such as auto-immune diseases and cancers, is a very innovative and competitive field. Although substantial efforts have been made in recent years to obtain specific and efficient antibodies, there is still room for improvement especially when considering a precise tissular targeting or increasing antigen affinity. A better understanding of the cellular and molecular steps of terminal B cell differentiation, in which an antigen-activated B cell becomes an antibody secreting cell, may improve antibody therapy. In this review, we use our recently published data about human B cell differentiation, to show that the mechanisms necessary to adapt a metamorphosing B cell to its new secretor

SUBMITTER: Lemarie M 

PROVIDER: S-EPMC8117215 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature