¹⁸F-Trifluoromethylated D-Cysteine as a Promising New PET Tracer for Glioma Imaging: Comparative Analysis With MRI and Histopathology in Orthotopic C6 Models.

ABSTRACT: Comparing MRI and histopathology, this study aims to comprehensively explore the potential application of ¹⁸F-trifluoromethylated D-cysteine (S-[¹⁸F]CF₃-D-CYS) in evaluating glioma by using orthotopic C6 glioma models. Sprague-Dawley (SD) rats (n = 9) were implanted with C6 glioma cells. Tumor growth was monitored every week by multiparameter MRI [including dynamic contrast-enhanced MRI (DCE-MRI)], [¹⁸F]FDG, S-[¹⁸F]CF₃-D-CYS, and [¹⁸F]FDOPA PET imaging. Repeated scans of the same rat with the two or three [¹⁸F]-labeled radiotracers were investigated. Initial regions of interest were manually delineated on T₂WI and set on the same level of PET images, and tumor-to-normal b

SUBMITTER: Ma H 

PROVIDER: S-EPMC8117348 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature