Targeting Premature Renal Aging: from Molecular Mechanisms of Cellular Senescence to Senolytic Trials.

ABSTRACT: The biological process of renal aging is characterized by progressive structural and functional deterioration of the kidney leading to end-stage renal disease, requiring renal replacement therapy. Since the discovery of pivotal mechanisms of senescence such as cell cycle arrest, apoptosis inhibition, and the development of a senescence-associated secretory phenotype (SASP), efforts in the understanding of how senescent cells participate in renal physiological and pathological aging have grown exponentially. This has been encouraged by both preclinical studies in animal models with senescent cell clearance or genetic depletion as well as due to evidence coming from the clinical oncologic experience. This review considers the molecular mechanism and pathways that trigger premature renal agin

SUBMITTER: Franzin R 

PROVIDER: S-EPMC8117359 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature