Dysbiosis of Oral Microbiota Associated with Palmoplantar Pustulosis.

ABSTRACT:

Background

Dysbiosis of oral microbiota is implicated not only in oral inflammatory lesions, but also in a variety of extraoral diseases. The etiology of palmoplantar pustulosis (PPP) remains unclear; however, it has been suggested that chronic inflammation caused by periodontopathic bacterial infection may play a role.

Objectives/methods

To determine whether patients with PPP have altered diversity and composition of oral microbiota, we conducted the 16S rDNA analysis using saliva samples collected from 21 outpatients with PPP and 10 healthy individuals.

Results

We found that the proportion of bacteria in the phylum Proteobacteria was significantly lower in PPP patients (p = 0.025). At the genus level, patients with PPP had a significantly lower abundance of Neisseri

SUBMITTER: Kageyama Y 

PROVIDER: S-EPMC8117382 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature