The Efficacy and Safety of Topical β-Blockers in Treating Infantile Hemangiomas: A Meta-Analysis Including 11 Randomized Controlled Trials.

ABSTRACT:

Background

To evaluate the efficacy and safety of topical β-blockers in the treatment of superficial infantile hemangiomas (SIH) and mixed infantile hemangiomas (MIH), respectively, and compare the efficacy and safety of topical β-blockers with other interventions.

Methods

The PRISMA guidelines were adhered to. We searched for randomized controlled trials in databases from 2010 to 2018 comparing topical β-blockers with other interventions for infantile hemangiomas. The outcomes evaluated were efficacy and adverse effects. Data analyses were performed using RevMan 5.3. Publication bias was assessed to account for bias in patient selection.

Results

Eleven studies, involving 1,235 patients, were subjected to this meta-analysis. Six studies compared topical β-blockers wit

SUBMITTER: Wang X 

PROVIDER: S-EPMC8117385 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature