Pituitary Function after High-Dose 177Lu-DOTATATE Therapy and Long-Term Follow-Up.

ABSTRACT:

Introduction

The pituitary gland has a high expression of somatostatin receptors and is therefore a potential organ at risk for radiation-induced toxicity after 177Lu-DOTATATE treatment.

Objective

To study changes in pituitary function in patients with neuroendocrine tumors (NETs) treated with dosimetry-based 177Lu-DOTATATE to detect possible late toxicity.

Methods

68 patients from a phase II clinical trial of dosimetry-based, individualized 177Lu-DOTATATE therapy were included in this analysis. Patients had received a median of 5 (range 3-9) treatment cycles of 7.4 GBq/cycle. Median follow-up was 30 months (range 11-89). The GH/IGF-1 axis, gonadotropins, and adrenal and thyroid axes were analyzed at baseline and on a yearly basis thereafter. Percent changes in hormon

SUBMITTER: Sundlov A 

PROVIDER: S-EPMC8117394 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature