Quantifying the dynamics of viral recombination during free virus and cell-to-cell transmission in HIV-1 infection.

ABSTRACT: Recombination has been shown to contribute to human immunodeficiency virus-1 (HIV-1) evolution in vivo, but the underlying dynamics are extremely complex, depending on the nature of the fitness landscapes and of epistatic interactions. A less well-studied determinant of recombinant evolution is the mode of virus transmission in the cell population. HIV-1 can spread by free virus transmission, resulting largely in singly infected cells, and also by direct cell-to-cell transmission, resulting in the simultaneous infection of cells with multiple viruses. We investigate the contribution of these two transmission pathways to recombinant evolution, by applying mathematical models to in vitro experimental data on the growth of fluorescent reporter viruses under static conditions (wh

SUBMITTER: Kreger J 

PROVIDER: S-EPMC8117450 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature