Regulatory involvement of the PerR and SloR metalloregulators in the Streptococcus mutans oxidative stress response.

ABSTRACT: Streptococcus mutans is a commensal of the human oral microbiome that can promote dental caries under conditions of dysbiosis. This study investigates metalloregulators and their involvement in the S. mutans oxidative stress response. Oxidative stress in the human mouth can derive from temporal increases in reactive oxygen species (ROS) after meal consumption and from endogenous bacterial ROS-producers that colonize the dentition. We hypothesize that the S. mutans PerR (SMU.593) and SloR (SMU.186) metalloregulatory proteins contribute to the regulation of oxidative stress genes and their products. Expression assays with S. mutans UA159 wild type cultures exposed to H₂O₂ reveal that H₂O₂ upregulates perR, and tha

SUBMITTER: Ruxin TR 

PROVIDER: S-EPMC8117520 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature