Large metabolic rewiring from small genomic changes between strains of Shigella flexneri.

ABSTRACT: The instability of Shigella genomes has been described, but how this instability causes phenotypic differences within the Shigella flexneri species is largely unknown and likely variable. We describe herein the genome of S. flexneri strain PE577, originally a clinical isolate, which exhibits several phenotypic differences compared to the model strain 2457T. Like many previously described strains of S. flexneri, PE577 lacks discernible, functional CRISPR and restriction-modification systems. Its phenotypic differences when compared to 2457T include lower transformation efficiency, higher oxygen sensitivity, altered carbon metabolism, and greater susceptibility to a wide variety of lytic bacteriophage isolates. Since relatively few Shigella phages have been

SUBMITTER: Doore SM 

PROVIDER: S-EPMC8117524 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature