The Streptococcus pyogenes signaling peptide SpoV regulates streptolysin O and enhances survival in murine blood.

ABSTRACT: Streptococcus pyogenes (Group A Streptococcus, GAS) is a human pathogen that causes a wide range of diseases. For successful colonization within a variety of host niches, GAS must sense and respond to environmental changes. Intercellular communication mediated by peptides is one way GAS coordinates gene expression in response to diverse environmental stressors, which enhances bacterial survival and contributes to virulence. Using peptidomics we identified SpoV (Streptococcal peptide controlling virulence) in culture supernatant fluids. SpoV is a secreted peptide encoded near the gene encoding the extracellular cholesterol-dependent cytolysin streptolysin O (slo) The addition of synthetic SpoV peptide derivatives, but not control peptides, increased slo transcript abundance in an M49 isolat

SUBMITTER: Herrera AL 

PROVIDER: S-EPMC8117530 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature