Low-density lipoprotein aggregation predicts adverse cardiovascular events in peripheral artery disease.

ABSTRACT:

Background and aims

Peripheral artery disease (PAD) is a systemic manifestation of atherosclerosis that is associated with a high risk of major adverse cardiovascular events (MACE). LDL aggregation contributes to atherosclerotic plaque progression and may contribute to plaque instability. We aimed to determine if LDL aggregation is associated with MACE in patients with PAD undergoing lower extremity revascularization (LER).

Methods

Two hundred thirty-nine patients with PAD undergoing LER had blood collected at baseline and were followed prospectively for MACE (myocardial infarction, stroke, cardiovascular death) for one year. Nineteen age, sex and LDL-C-matched control subjects without cardiovascular disease also had blood drawn. Subject LDL was exposed to sphingomyelinase a

SUBMITTER: Heffron SP 

PROVIDER: S-EPMC8117546 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature