Genetic variant of MIR4300HG is associated with progression of adolescent idiopathic scoliosis in a Chinese population.

ABSTRACT:

Background

A recent genome-wide association study identified a susceptible locus in MIR4300HG gene that was associated with curve progression of adolescent idiopathic scoliosis (AIS) in the Japanese population. However, the association between the gene and curve progression in other populations remains unclear.

Methods

A cohort of 1952 AIS patients and 2495 healthy controls were included in the case-control analysis. In the case-only analysis, 747 patients were assigned to the progression group and 520 patients were assigned to the non-progression group, respectively. Rs35333564 was genotyped for all the subjects. Paraspinal muscles of 76 patients were collected for the analysis of gene expression. Chi-square test and ANOVA test were used for the intergroup comparison. Pears

SUBMITTER: Wang Y 

PROVIDER: S-EPMC8117547 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature