Association of TNF-α -308G > A polymorphism with susceptibility to tendinopathy in athletes: a case-control study.

ABSTRACT:

Background

High levels of the tumor necrosis factor alpha (TNF-α) induce apoptosis and pro-inflammatory effects for primary degeneration of tendon and development of tendinopathy. The aim of this study was to investigate the association between the TNF-α polymorphisms and tendinopathy in athletes.

Methods

Two hundred and seventy athletes (135 tendinopathy cases and 135 controls) were included and genotyped (TNF-α -1031T > C; -857 C > T; -308G > A) using TaqMan validated assays. The association of the polymorphisms with tendinopathy was evaluated by a multivariate logistic regression model, using odds ratios (OR) and 95 % confidence intervals (CI).

Results

The variant allele - 308 A was significantly associated with patellar (OR: 1.9; 95 % CI: 1.01-3.6) or Achilles ten

SUBMITTER: Lopes LR 

PROVIDER: S-EPMC8117576 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature