Identification of prognosis-related molecular subgroups based on DNA methylation in pancreatic cancer.

ABSTRACT:

Background

Pancreatic cancer (PC) is one of the most lethal and aggressive cancer malignancies. The lethality of PC is associated with delayed diagnosis, presence of distant metastasis, and its easy relapse. It is known that clinical treatment decisions are still mainly based on the clinical stage and pathological grade, which are insufficient to determine an appropriate treatment. Considering the significant heterogeneity of PC biological characteristics, the current clinical classificatory pattern relying solely on classical clinicopathological features identification needs to be urgently improved. In this study, we conducted in-depth analyses to establish prognosis-related molecular subgroups based on DNA methylation signature.

Results

DNA methylation, RNA sequencing, som

SUBMITTER: Yin X 

PROVIDER: S-EPMC8117591 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature