Integrative genomics of the mammalian alveolar macrophage response to intracellular mycobacteria.

ABSTRACT:

Background

Bovine TB (bTB), caused by infection with Mycobacterium bovis, is a major endemic disease affecting global cattle production. The key innate immune cell that first encounters the pathogen is the alveolar macrophage, previously shown to be substantially reprogrammed during intracellular infection by the pathogen. Here we use differential expression, and correlation- and interaction-based network approaches to analyse the host response to infection with M. bovis at the transcriptome level to identify core infection response pathways and gene modules. These outputs were then integrated with genome-wide association study (GWAS) data sets to enhance detection of genomic variants for susceptibility/resistance to M. bovis infection.

Results

The host gene expression data

SUBMITTER: Hall TJ 

PROVIDER: S-EPMC8117616 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature