Skeletal Muscle ACSL Isoforms Relate to Measures of Fat Metabolism in Humans.

ABSTRACT:

Introduction

Evidence from model systems implicates long-chain acyl-coenzyme A synthetase (ACSL) as key regulators of skeletal muscle fat oxidation and fat storage; however, such roles remain underexplored in humans.

Purpose

We sought to determine the protein expression of ACSL isoforms in skeletal muscle at rest and in response to acute exercise and identify relationships between skeletal muscle ACSL and measures of fat metabolism in humans.

Methods

Sedentary adults (n = 14 [4 males and 10 females], body mass index = 22.2 ± 2.1 kg·m-2, V˙O2max = 32.2 ± 4.5 mL·kg-1⋅min-1) completed two study visits. Trials were identical other than completing 1 h of cycling exercise (65% V˙O2max) or remaining sedentary. Vastus lateralis biopsies were obtained 15-min postexercise (or r

SUBMITTER: Stierwalt HD 

PROVIDER: S-EPMC8117722 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature