Studies of 3D directed cell migration enabled by direct laser writing of curved wave topography.

ABSTRACT: Cell migration, critical to numerous biological processes, can be guided by surface topography. Studying the effects of topography on cell migration is valuable for enhancing our understanding of directional cell migration and for functionally engineering cell behavior. However, fabrication limitations constrain topography studies to geometries that may not adequately mimic physiological environments. Direct Laser Writing (DLW) provides the necessary 3D flexibility and control to create well-defined waveforms with curvature and length scales that are similar to those found in physiological settings, such as the luminal walls of blood vessels that endothelial cells migrate along. We find that endothelial cells migrate fastest along square waves, intermediate along triangular waves, and slow

SUBMITTER: Cheng D 

PROVIDER: S-EPMC8117727 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature