Development of systemic immune dysregulation in a rat trauma model of biomaterial-associated infection.

ABSTRACT: Orthopedic biomaterial-associated infections remain a major clinical challenge, with Staphylococcus aureus being the most common pathogen. S. aureus biofilm formation enhances immune evasion and antibiotic resistance, resulting in a local, indolent infection that can persist long-term without symptoms before eventual hardware failure, bone non-union, or sepsis. Immune modulation is an emerging strategy to combat host immune evasion by S. aureus. However, most immune modulation strategies are focused on local immune responses at the site of infection, with little emphasis on understanding the infection-induced and orthopedic-related systemic immune responses of the host, and their role in local infection clearance and tissue regeneration. This study utilized a rat bone defect model to inves

SUBMITTER: Vantucci CE 

PROVIDER: S-EPMC8117743 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature