Identification and Predictions Regarding the Biosynthesis Pathway of Polyene Macrolides Produced by Streptomyces roseoflavus Men-myco-93-63.

ABSTRACT: A group of polyene macrolides mainly composed of two constituents was isolated from the fermentation broth of Streptomyces roseoflavus Men-myco-93-63, which was isolated from soil where potato scabs were repressed naturally. One of these macrolides was roflamycoin, which was first reported in 1968, and the other was a novel compound named Men-myco-A, which had one methylene unit more than roflamycoin. Together, they were designated RM. This group of antibiotics exhibited broad-spectrum antifungal activities in vitro against 17 plant-pathogenic fungi, with 50% effective concentrations (EC₅₀) of 2.05 to 7.09 μg/ml and 90% effective concentrations (EC₉₀) of 4.32 to 54.45 μg/ml, which indicates their potential use in plant disease control. Furthermore, their

SUBMITTER: Han X 

PROVIDER: S-EPMC8117769 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature