Neuroinflammation in cognitive decline post-cardiac surgery (the FOCUS study): an observational study protocol.

ABSTRACT:

Introduction

Postoperative cognitive dysfunction occurs frequently after coronary artery bypass grafting (CABG). The underlying mechanisms remain poorly understood, but neuroinflammation might play a pivotal role. We hypothesise that systemic inflammation induced by the surgical trauma could activate the innate immune (glial) cells of the brain. This could lead to an exaggerated neuroinflammatory cascade, resulting in neuronal dysfunction and loss of neuronal cells. Therefore, the aims of this study are to assess neuroinflammation in vivo presurgery and postsurgery in patients undergoing major cardiac surgery and investigate whether there is a relationship of neuroinflammation to cognitive outcomes, changes to brain structure and function, and systemic inflammation.

Methods and

SUBMITTER: Peters van Ton AM 

PROVIDER: S-EPMC8118022 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature