Outcome Prognostication of Acute Brain Injury using the Neurological Pupil Index (ORANGE) study: protocol for a prospective, observational, multicentre, international cohort study.

ABSTRACT:

Introduction

The pupillary examination is an important part of the neurological assessment, especially in the setting of acutely brain-injured patients, and pupillary abnormalities are associated with poor outcomes. Currently, the pupillary examination is based on a visual, subjective and frequently inaccurate estimation. The use of automated infrared pupillometry to measure the pupillary light reflex can precisely quantify subtle changes in pupillary functions. The study aimed to evaluate the association between abnormal pupillary function, assessed by the Neurological Pupil Index (NPi), and long-term outcomes in patients with acute brain injury (ABI).

Methods and analysis

The Outcome Prognostication of Acute Brain Injury using the Neurological Pupil Index study is a prospe

SUBMITTER: Oddo M 

PROVIDER: S-EPMC8118033 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature