Change in cognition and body mass index in relation to preclinical dementia.

ABSTRACT:

Introduction

To study if declining cognition drives weight loss in preclinical dementia, we examined the longitudinal association between body mass index (BMI) and cognitive abilities in individuals who did or did not later develop dementia.

Methods

Using data from individuals spanning age 50 to 89, we applied dual change score models separately in individuals who remained cognitively intact (n = 1498) and those who were diagnosed with dementia within 5 years of last assessment (n = 459).

Results

Among the cognitively intact, there was a bidirectional association: Stable BMI predicted stable cognition and vice versa. Among individuals who were subsequently diagnosed with dementia, the association was unidirectional: Higher BMI predicted declining cognition but cogniti

SUBMITTER: Karlsson IK 

PROVIDER: S-EPMC8118197 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature