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Ten steps to investigate a cellular system with mathematical modeling.


ABSTRACT: Cellular and intracellular processes are inherently complex due to the large number of components and interactions, which are often nonlinear and occur at different spatiotemporal scales. Because of this complexity, mathematical modeling is increasingly used to simulate such systems and perform experiments in silico, many orders of magnitude faster than real experiments and often at a higher spatiotemporal resolution. In this article, we will focus on the generic modeling process and illustrate it with an example model of membrane lipid turnover.

SUBMITTER: King J 

PROVIDER: S-EPMC8118325 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature

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Ten steps to investigate a cellular system with mathematical modeling.

King Jasia J   Eroumé Kerbaï Saïd KS   Truckenmüller Roman R   Giselbrecht Stefan S   Cowan Ann E AE   Loew Leslie L   Carlier Aurélie A  

PLoS computational biology 20210513 5


Cellular and intracellular processes are inherently complex due to the large number of components and interactions, which are often nonlinear and occur at different spatiotemporal scales. Because of this complexity, mathematical modeling is increasingly used to simulate such systems and perform experiments in silico, many orders of magnitude faster than real experiments and often at a higher spatiotemporal resolution. In this article, we will focus on the generic modeling process and illustrate  ...[more]

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