Effects of intensive blood pressure control on mortality and cardiorenal function in chronic kidney disease patients.

ABSTRACT:

Background

Blood pressure (BP) variability is highly correlated with cardiovascular and kidney outcomes in patients with chronic kidney disease (CKD). However, appropriate BP targets in patients with CKD remain uncertain.

Methods

We searched PubMed, Embase, and the Cochrane Library for randomized controlled trials (RCTs) of CKD patients who underwent intensive BP management. Kappa score was used to assess inter-rater agreement. A good agreement between the authors was observed to inter-rater reliability of RCTs selection (kappa = 0.77; P = 0.005).

Results

Ten relevant studies involving 20 059 patients were included in the meta-analysis. Overall, intensive BP management may reduce the incidence of cardiovascular disease mortality (RR: 0.69, 95% CI: 0.53 to 0.90,

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC8118417 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature