Neuraminidase-associated plasminogen recruitment enables systemic spread of natural avian Influenza viruses H3N1.

ABSTRACT: Repeated outbreaks due to H3N1 low pathogenicity avian influenza viruses (LPAIV) in Belgium were associated with unusually high mortality in chicken in 2019. Those events caused considerable economic losses and prompted restriction measures normally implemented for eradicating high pathogenicity avian influenza viruses (HPAIV). Initial pathology investigations and infection studies suggested this virus to be able to replicate systemically, being very atypical for H3 LPAIV. Here, we investigate the pathogenesis of this H3N1 virus and propose a mechanism explaining its unusual systemic replication capability. By intravenous and intracerebral inoculation in chicken, we demonstrate systemic spread of this virus, extending to the central nervous system. Endoproteolytic viral hemagglutinin (HA)

SUBMITTER: Schon J 

PROVIDER: S-EPMC8118554 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature