Genetic and Metabolic Determinants of Plasma Levels of ANGPTL8.

ABSTRACT:

Context

ANGPTL8 (A8) plays a key role in determining the tissue fate of circulating triglycerides (TGs). Plasma A8 levels are associated with several parameters of glucose and TG metabolism, but the causality of these relationships and the contribution of genetic variants to differences in A8 levels have not been explored.

Objective

To characterize the frequency distribution of plasma A8 levels in a diverse population using a newly-developed enzyme-linked immunosorbent assay (ELISA) and to identify genetic factors contributing to differences in plasma A8 levels.

Methods

We studied a population-based sample of Dallas County, comprising individuals in the Dallas Heart Study (DHS-1, n = 3538; DHS-2, n = 3283), including 2131 individuals with repeated measurements 7 to 9

SUBMITTER: Oldoni F 

PROVIDER: S-EPMC8118582 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature