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Tau: Enabler of diverse brain disorders and target of rapidly evolving therapeutic strategies.

ABSTRACT: Several lines of evidence implicate the protein tau in the pathogenesis of multiple brain disorders, including Alzheimer's disease, other neurodegenerative conditions, autism, and epilepsy. Tau is abundant in neurons and interacts with microtubules, but its main functions in the brain remain to be defined. These functions may involve the regulation of signaling pathways relevant to diverse biological processes. Informative disease models have revealed a plethora of abnormal tau species and mechanisms that might contribute to neuronal dysfunction and loss, but the relative importance of their respective contributions is uncertain. This knowledge gap poses major obstacles to the development of truly impactful therapeutic strategies. The current expansion and intensification of efforts to translate mechanistic insights into tau-related therapeutics should address this issue and could deliver better treatments for a host of devastating conditions.

SUBMITTER: Chang CW

PROVIDER: S-EPMC8118650 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature

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Tau: Enabler of diverse brain disorders and target of rapidly evolving therapeutic strategies.

Chang Che-Wei CW Shao Eric E Mucke Lennart L

Science (New York, N.Y.) 20210201 6532

Several lines of evidence implicate the protein tau in the pathogenesis of multiple brain disorders, including Alzheimer's disease, other neurodegenerative conditions, autism, and epilepsy. Tau is abundant in neurons and interacts with microtubules, but its main functions in the brain remain to be defined. These functions may involve the regulation of signaling pathways relevant to diverse biological processes. Informative disease models have revealed a plethora of abnormal tau species and mecha ...[more]

PMID: 33632820

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