Dataset Information

Insights from a Pan India Sero-Epidemiological survey (Phenome-India Cohort) for SARS-CoV2.

ABSTRACT: To understand the spread of SARS-CoV2, in August and September 2020, the Council of Scientific and Industrial Research (India) conducted a serosurvey across its constituent laboratories and centers across India. Of 10,427 volunteers, 1058 (10.14%) tested positive for SARS-CoV2 anti-nucleocapsid (anti-NC) antibodies, 95% of which had surrogate neutralization activity. Three-fourth of these recalled no symptoms. Repeat serology tests at 3 (n = 607) and 6 (n = 175) months showed stable anti-NC antibodies but declining neutralization activity. Local seropositivity was higher in densely populated cities and was inversely correlated with a 30-day change in regional test positivity rates (TPRs). Regional seropositivity above 10% was associated with declining TPR. Personal factors associated with higher odds of seropositivity were high-exposure work (odds ratio, 95% confidence interval, p value: 2.23, 1.92-2.59, <0.0001), use of public transport (1.79, 1.43-2.24, <0.0001), not smoking (1.52, 1.16-1.99, 0.0257), non-vegetarian diet (1.67, 1.41-1.99, <0.0001), and B blood group (1.36, 1.15-1.61, 0.001).

SUBMITTER: Naushin S

PROVIDER: S-EPMC8118652 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature

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Insights from a Pan India Sero-Epidemiological survey (Phenome-India Cohort) for SARS-CoV2.

Naushin Salwa S Sardana Viren V Ujjainiya Rajat R Bhatheja Nitin N Kutum Rintu R Bhaskar Akash Kumar AK Pradhan Shalini S Prakash Satyartha S Khan Raju R Rawat Birendra Singh BS Tallapaka Karthik Bharadwaj KB Anumalla Mahesh M Chandak Giriraj Ratan GR Lahiri Amit A Kar Susanta S Mulay Shrikant Ramesh SR Mugale Madhav Nilakanth MN Srivastava Mrigank M Khan Shaziya S Srivastava Anjali A Tomar Bhawana B Veerapandian Murugan M Venkatachalam Ganesh G Vijayakumar Selvamani Raja SR Agarwal Ajay A Gupta Dinesh D Halami Prakash M PM Peddha Muthukumar Serva MS Sundaram Gopinath M GM Veeranna Ravindra P RP Pal Anirban A Agarwal Vinay Kumar VK Maurya Anil Ku AK Singh Ranvijay Kumar RK Raman Ashok Kumar AK Anandasadagopan Suresh Kumar SK Karuppanan Parimala P Venkatesan Subramanian S Sardana Harish Kumar HK Kothari Anamika A Jain Rishabh R Thakur Anupama A Parihar Devendra Singh DS Saifi Anas A Kaur Jasleen J Kumar Virendra V Mishra Avinash A Gogeri Iranna I Rayasam Geethavani G Singh Praveen P Chakraborty Rahul R Chaturvedi Gaura G Karunakar Pinreddy P Yadav Rohit R Singhmar Sunanda S Singh Dayanidhi D Sarkar Sharmistha S Bhattacharya Purbasha P Acharya Sundaram S Singh Vandana V Verma Shweta S Soni Drishti D Seth Surabhi S Vashisht Sakshi S Thakran Sarita S Fatima Firdaus F Singh Akash Pratap AP Sharma Akanksha A Sharma Babita B Subramanian Manikandan M Padwad Yogendra S YS Hallan Vipin V Patial Vikram V Singh Damanpreet D Tripude Narendra Vijay NV Chakrabarti Partha P Maity Sujay Krishna SK Ganguly Dipyaman D Sarkar Jit J Ramakrishna Sistla S Kumar Balthu Narender BN Kumar Kiran A KA Gandhi Sumit G SG Jamwal Piyush Singh PS Chouhan Rekha R Jamwal Vijay Lakshmi VL Kapoor Nitika N Ghosh Debashish D Thakkar Ghanshyam G Subudhi Umakanta U Sen Pradip P Chaudhury Saumya Ray SR Kumar Rashmi R Gupta Pawan P Tuli Amit A Sharma Deepak D Ringe Rajesh P RP D Amarnarayan A Kulkarni Mahesh M Shanmugam Dhansekaran D Dharne Mahesh S MS Dastager Sayed G SG Joshi Rakesh R Patil Amita P AP Mahajan Sachin N SN Khan Abujunaid Habib AH Wagh Vasudev V Yadav Rakesh Kumar RK Khilari Ajinkya A Bhadange Mayuri M Chaurasiya Arvindkumar H AH Kulsange Shabda E SE Khairnar Krishna K Paranjape Shilpa S Kalita Jatin J Sastry Narahari G NG Phukan Tridip T Manna Prasenjit P Romi Wahengbam W Bharali Pankaj P Ozah Dibyajyoti D Sahu Ravi Kumar RK Babu Elapavalooru Vssk EV Sukumaran Rajeev R Nair Aiswarya R AR Valappil Prajeesh Kooloth PK Puthiyamadam Anoop A Velayudhanpillai Adarsh A Chodankar Kalpana K Damare Samir S Madhavi Yennapu Y Aggarwal Ved Varun VV Dahiya Sumit S Agrawal Anurag A Dash Debasis D Sengupta Shantanu S

eLife 20210420

To understand the spread of SARS-CoV2, in August and September 2020, the Council of Scientific and Industrial Research (India) conducted a serosurvey across its constituent laboratories and centers across India. Of 10,427 volunteers, 1058 (10.14%) tested positive for SARS-CoV2 anti-nucleocapsid (anti-NC) antibodies, 95% of which had surrogate neutralization activity. Three-fourth of these recalled no symptoms. Repeat serology tests at 3 (n = 607) and 6 (n = 175) months showed stable anti-NC anti ...[more]

PMID: 33876727

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Project description:BackgroundCoxiella burnetii is a widely distributed pathogen, but data on its epidemiology in livestock, and human populations remain scanty, especially in developing countries such as Kenya. We used the One Health approach to estimate the seroprevalance of C. burnetii in cattle, sheep, goats and human populations in Tana River county, and in humans in Garissa county, Kenya. We also identified potential determinants of exposure among these hosts.MethodsData were collected through a cross-sectional study. Serum samples were taken from 2,727 animals (466 cattle, 1,333 goats, and 928 sheep) and 974 humans and screened for Phase I/II IgG antibodies against C. burnetii using enzyme-linked immunosorbent assay (ELISA). Data on potential factors associated with animal and human exposure were collected using a structured questionnaire. Multivariable analyses were performed with households as a random effect to adjust for the within-household correlation of C. burnetii exposure among animals and humans, respectively.ResultsThe overall apparent seroprevalence estimates of C. burnetii in livestock and humans were 12.80% (95% confidence interval [CI]: 11.57-14.11) and 24.44% (95% CI: 21.77-27.26), respectively. In livestock, the seroprevalence differed significantly by species (p < 0.01). The highest seroprevalence estimates were observed in goats (15.22%, 95% CI: 13.34-17.27) and sheep (14.22%, 95% CI: 12.04-16.64) while cattle (3.00%, 95% CI: 1.65-4.99) had the lowest seroprevalence. Herd-level seropositivity of C. burnetii in livestock was not positively associated with human exposure. Multivariable results showed that female animals had higher odds of seropositivity for C. burnetii than males, while for animal age groups, adult animals had higher odds of seropositivity than calves, kids or lambs. For livestock species, both sheep and goats had significantly higher odds of seropositivity than cattle. In human populations, men had a significantly higher odds of testing positive for C. burnetii than women.ConclusionsThis study provides evidence of livestock and human exposure to C. burnetii which could have serious economic implications on livestock production and impact on human health. These results also highlight the need to establish active surveillance in the study area to reduce the disease burden associated with this pathogen.

Dataset Information

Insights from a Pan India Sero-Epidemiological survey (Phenome-India Cohort) for SARS-CoV2.

Publications

Insights from a Pan India Sero-Epidemiological survey (Phenome-India Cohort) for SARS-CoV2.

Similar Datasets

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