Clinical features and prognostic factors in Covid-19: A prospective cohort study.

ABSTRACT:

Background

Mortality rates are high among hospitalized patients with COVID-19, especially in those intubated on the ICU. Insight in pathways associated with unfavourable outcome may lead to new treatment strategies.

Methods

We performed a prospective cohort study of patients with COVID-19 admitted to general ward or ICU who underwent serial blood sampling. To provide insight in the pathways involved in disease progression, associations were estimated between outcome risk and serial measurements of 64 biomarkers in potential important pathways of COVID-19 infection (inflammation, tissue damage, complement system, coagulation and fibrinolysis) using joint models combining Cox regression and linear mixed-effects models. For patients admitted to the general ward, the primary out

SUBMITTER: de Bruin S 

PROVIDER: S-EPMC8118723 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature