Molecular mapping of interstitial lung disease reveals a phenotypically distinct senescent basal epithelial cell population.

ABSTRACT: Compromised regenerative capacity of lung epithelial cells can lead to cellular senescence, which may precipitate fibrosis. While increased markers of senescence have been reported in idiopathic pulmonary fibrosis (IPF), the origin and identity of these senescent cells remain unclear, and tools to characterize context-specific cellular senescence in human lung are lacking. We observed that the senescent marker p16 is predominantly localized to bronchiolized epithelial structures in scarred regions of IPF and systemic sclerosis-associated interstitial lung disease (SSc-ILD) lung tissue, overlapping with the basal epithelial markers Keratin 5 and Keratin 17. Using in vitro models, we derived transcriptional signatures of senescence programming specific to different types of lung epithelial c

SUBMITTER: DePianto DJ 

PROVIDER: S-EPMC8119199 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature