Ivermectin effectively inhibits hepatitis E virus replication, requiring the host nuclear transport protein importin α1.
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ABSTRACT:
SUBMITTER: Li Y
PROVIDER: S-EPMC8119233 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
Publications
Ivermectin effectively inhibits hepatitis E virus replication, requiring the host nuclear transport protein importin α1.
Li Yunlong Y Miao Zhijiang Z Li Pengfei P Zhang Ruyi R Kainov Denis E DE Ma Zhongren Z de Man Robert A RA Peppelenbosch Maikel P MP Pan Qiuwei Q
Archives of virology 20210514 7
We show that ivermectin, an FDA-approved anti-parasitic drug, effectively inhibits infection with hepatitis E virus (HEV) genotypes 1 and 3 in a range of cell culture models, including hepatic and extrahepatic cells. Long-term treatment showed no clear evidence of the development of drug resistance. Gene silencing of importin-α1, a cellular target of ivermectin and a key member of the host nuclear transport complex, inhibited viral replication and largely abolished the anti-HEV effect of ivermec ...[more]
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