Developmental effects on sleep-wake patterns in infants receiving a cow's milk-based infant formula with an added prebiotic blend: a Randomized Controlled Trial.

ABSTRACT:

Background

Few studies have evaluated nutritive effects of prebiotics on infant behavior state, physiology, or metabolic status.

Methods

In this double-blind randomized study, infants (n = 161) received cow's milk-based infant formula (Control) or similar formula with an added prebiotic blend (polydextrose and galactooligosaccharides [PDX/GOS]) from 14-35 to 112 days of age. Infant wake behavior (crying/fussing, awake/content) and 24-h sleep-wake actograms were analyzed (Baseline, Days 70 and 112). Salivary cortisol was immunoassayed (Days 70 and 112). In a subset, exploratory stool 16S ribosomal RNA-sequencing was analyzed (Baseline, Day 112).

Results

One hundred and thirty-one infants completed the study. Average duration of crying/fussing episodes was similar at Ba

SUBMITTER: Colombo J 

PROVIDER: S-EPMC8119237 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature