Biomarkers of neonatal skin barrier adaptation reveal substantial differences compared to adult skin.

ABSTRACT:

Background

The objective of this study was to measure skin characteristics in premature (PT), late preterm (LPT), and full-term (FT) neonates compared with adults at two times (T1, T2).

Methods

Skin samples of 61 neonates and 34 adults were analyzed for protein biomarkers, natural moisturizing factor (NMF), and biophysical parameters. Infant groups were: <34 weeks (PT), 34-<37 weeks (LPT), and ≥37 weeks (FT).

Results

Forty proteins were differentially expressed in FT infant skin, 38 in LPT infant skin, and 12 in PT infant skin compared with adult skin at T1. At T2, 40 proteins were differentially expressed in FT infants, 38 in LPT infants, and 54 in PT infants compared with adults. All proteins were increased at both times, except TMG3, S100A7, and PEBP1, and decrease

SUBMITTER: Visscher MO 

PROVIDER: S-EPMC8119241 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature