Increased regional homogeneity modulated by metacognitive training predicts therapeutic efficacy in patients with schizophrenia.

ABSTRACT: Previous studies have demonstrated the efficacy of metacognitive training (MCT) in schizophrenia. However, the underlying mechanisms related to therapeutic effect of MCT remain unknown. The present study explored the treatment effects of MCT on brain regional neural activity using regional homogeneity (ReHo) and whether these regions' activities could predict individual treatment response in schizophrenia. Forty-one patients with schizophrenia and 20 healthy controls were scanned using resting-state functional magnetic resonance imaging. Patients were randomly divided into drug therapy (DT) and drug plus psychotherapy (DPP) groups. The DT group received only olanzapine treatment, whereas the DPP group received olanzapine and MCT for 8 weeks. The results revealed that ReHo in the right prec

SUBMITTER: Shan X 

PROVIDER: S-EPMC8119286 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature