ATN incorporating cerebrospinal fluid neurofilament light chain detects frontotemporal lobar degeneration.

ABSTRACT:

Introduction

The ATN framework provides an in vivo diagnosis of Alzheimer's disease (AD) using cerebrospinal fluid (CSF) biomarkers of pathologic amyloid plaques (A), tangles (T), and neurodegeneration (N). ATN is rarely evaluated in pathologically confirmed patients and its poor sensitivity to suspected non-Alzheimer's pathophysiologies (SNAP), including frontotemporal lobar degeneration (FTLD), leads to misdiagnoses. We compared accuracy of ATN (ATN_TAU ) using CSF total tau (t-tau) to a modified strategy (ATN_NfL ) using CSF neurofilament light chain (NfL) in an autopsy cohort.

Methods

ATN_TAU and ATN_NfL were trained in an independent sample and validated in autopsy-confirmed AD (n = 67) and FTLD (n = 27).

Results

ATN_Nf

SUBMITTER: Cousins KAQ 

PROVIDER: S-EPMC8119305 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature