Long-term inflammatory pain does not impact exploratory behavior and stress coping strategies in mice.

ABSTRACT:

Abstract

Pain puts patients at risk for developing psychiatric conditions such as anxiety and depression. Preclinical mouse models of pain-induced affective behavior vary widely in methodology and results, impairing progress towards improved therapeutics. To systematically investigate the effect of long-term inflammatory pain on exploratory behavior and stress coping strategy, we assessed male C57BL/6J mice in the forced swim test (FST), elevated zero maze, and open field test at 4 and 6 weeks postinjection of Complete Freund's Adjuvant, while controlling for testing order and combination. Inflammatory pain did not induce a passive stress coping strategy in the FST and did not reduce exploratory behavior in the elevated zero maze or the open field test. Using systematic correlation

SUBMITTER: Burek DJ 

PROVIDER: S-EPMC8119306 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature