A peptide encoded within a 5' untranslated region promotes pain sensitization in mice.

ABSTRACT:

Abstract

Translational regulation permeates neuronal function. Nociceptors are sensory neurons responsible for the detection of harmful stimuli. Changes in their activity, termed plasticity, are intimately linked to the persistence of pain. Although inhibitors of protein synthesis robustly attenuate pain-associated behavior, the underlying targets that support plasticity are largely unknown. Here, we examine the contribution of protein synthesis in regions of RNA annotated as noncoding. Based on analyses of previously reported ribosome profiling data, we provide evidence for widespread translation in noncoding transcripts and regulatory regions of mRNAs. We identify an increase in ribosome occupancy in the 5' untranslated regions of the calcitonin gene-related peptide (CGRP/Calca).

SUBMITTER: Barragan-Iglesias P 

PROVIDER: S-EPMC8119312 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature