Prenatal exposure to per- and polyfluoroalkyl substances and cognitive development in infancy and toddlerhood.

ABSTRACT:

Background/objective

Per- and polyfluoroalkyl substances (PFAS) have neurobehavioral toxicity in experimental studies. Evidence on associations between prenatal PFAS exposure and child's cognitive development is inconsistent partly due to differences in assessment time points and tools. We examined associations of prenatal maternal serum PFAS concentrations with child's cognitive development assessed at multiple time points in infancy and toddlerhood.

Methods

We included 140 mother-child pairs from MARBLES (Markers of Autism Risk in Babies - Learning Early Signs), a longitudinal cohort of children with a first degree relative who was diagnosed with autism spectrum disorder followed from birth. Study children's cognitive development was assessed at 6, 12, 24, and 36 months of

SUBMITTER: Oh J 

PROVIDER: S-EPMC8119322 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature