Association between cumulative childhood blood lead exposure and hepatic steatosis in young Mexican adults.

ABSTRACT:

Background

Exposure to environmental toxicants may play a role in the pathogenesis of Non Alcoholic Fatty Liver Disease (NAFLD). Cumulative exposure to lead (Pb) has chronic and permanent effects on liver function. Pediatric populations are vulnerable to the toxic effects of Pb, even at low exposure levels. The purpose of the study was to estimate the association between cumulative Pb exposure during childhood and hepatic steatosis biomarkers in young Mexican adults.

Methods

A subsample of 93 participants from the ELEMENT cohort were included in this study. Childhood blood samples were collected annually from ages 1-4 years and were used to calculate the Cumulative Childhood Blood Lead Levels (CCBLL). Hepatic steatosis during adulthood was defined as an excessive accumulatio

SUBMITTER: Betanzos-Robledo L 

PROVIDER: S-EPMC8119339 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature