Diet, psychosocial stress, and Alzheimer's disease-related neuroanatomy in female nonhuman primates.

ABSTRACT:

Introduction

Associations between diet, psychosocial stress, and neurodegenerative disease, including Alzheimer's disease (AD), have been reported, but causal relationships are difficult to determine in human studies.

Methods

We used structural magnetic resonance imaging in a well-validated non-human primate model of AD-like neuropathology to examine the longitudinal effects of diet (Mediterranean vs Western) and social subordination stress on brain anatomy, including global volumes, cortical thicknesses and volumes, and 20 individual regions of interest (ROIs).

Results

Western diet resulted in greater cortical thicknesses, total brain volumes, and gray matter, and diminished cerebrospinal fluid and white matter volumes. Socially stressed subordinates had smaller whol

SUBMITTER: Frye BM 

PROVIDER: S-EPMC8119381 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature