Ratio of venous-to-arterial PCO₂ to arteriovenous oxygen content difference during regional ischemic or hypoxic hypoxia.

ABSTRACT: The purpose of the study was to evaluate the behavior of the venous-to-arterial CO₂ tension difference (ΔPCO₂) over the arterial-to-venous oxygen content difference (ΔO₂) ratio (ΔPCO₂/ΔO₂) and the difference between venous-to-arterial CO₂ content calculated with the Douglas' equation (ΔCCO_2D) over ΔO₂ ratio (ΔCCO_2D/ΔO₂) and their abilities to reflect the occurrence of anaerobic metabolism in two experimental models of tissue hypoxia: ischemic hypoxia (IH) and hypoxic hypoxia (HH). We also aimed to assess the influence of metabolic acidosis and Haldane effects on the PCO₂/CO₂ content relationship. In a vascularly isolated, innervated dog hindlimb perfused with

SUBMITTER: Mallat J 

PROVIDER: S-EPMC8119496 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature