Role of the Peripheral Nervous System in PD Pathology, Diagnosis, and Treatment.

ABSTRACT: Studies on Parkinson disease (PD) have mostly focused on the central nervous system-specifically, on the loss of mesencephalic dopaminergic neurons and associated motor dysfunction. However, the peripheral nervous system (PNS) is gaining prominence in PD research, with increasing clinical attention being paid to non-motor symptoms. Researchers found abnormal deposition of α-synuclein and neuroinflammation in the PNS. Attempts have been made to use these pathological changes during the clinical diagnosis of PD. Animal studies demonstrated that combined transplantation of autologous peripheral nerves and cells with tyrosine hydroxylase activity can reduce dopaminergic neuronal damage, and similar effects were observed in some clinical trials. In this review, we will systematically explain PN

SUBMITTER: Ma C 

PROVIDER: S-EPMC8119739 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature