Blood pressure reduction and anti-hypertensive treatment choice: A post-hoc analysis of the SPRINT trial.

ABSTRACT:

Background

Uncontrolled blood pressure (BP) increases the risk of major adverse cardiovascular events. In SPRINT an intensive versus standard BP lowering strategy resulted in a lower rate of cardiovascular events and death. Whether BP reduction only or also the choice of anti-hypertensive drugs is associated with outcomes remains to be elucidated.

Aims

We aim to study the association of BP and different anti-hypertensive drugs with several cardiovascular outcomes.

Methods

Time-updated Cox and mixed-effects models. The primary outcome was a composite of first myocardial infarction, acute coronary syndrome, stroke, heart failure, or cardiovascular death.

Results

A total of 9361 patients were included. The anti-hypertensive agents most frequently used were ACEi/AR

SUBMITTER: Ferreira JP 

PROVIDER: S-EPMC8119807 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature