Modifiable risk factors for epilepsy: A two-sample Mendelian randomization study.

ABSTRACT:

Introduction

We conducted a two-sample Mendelian randomization study to determine the associations of modifiable risk factors with epilepsy.

Methods

Fourteen potential risk factors for epilepsy were selected based on a systematic review of risk factors for epilepsy. Single-nucleotide polymorphisms associated with each exposure at the genome-wide significance threshold (p < 5×10^-8 ) were proposed as instrumental variables from corresponding genome-wide association studies. Summary-level data for epilepsy were obtained from the FinnGen consortium (4,588 cases and 144 780 noncases). Potential causal associations (p < .05) were attempted for replication using UK Biobank data (901 cases and 395 209 controls).

Results

Among 14 potential risk factors, 4 showed sig

SUBMITTER: Yuan S 

PROVIDER: S-EPMC8119863 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature